That's a little over the top, I think.
But your post is ambiguous. Are you talking about a single physical drive partitioned into two (as implied by the post title) or two separate hard drives (
cf you post text)?
Here's what I'd do:
With one drive, I'd partition it in three. I'd make the outermost (C) partition just big enough for the operating system. I'd make the next innermost partition (D) just big enough for one project. The final partition (E) would be where I kept all my current projects. When I wanted to work on a project, I'd archive the current version of whatever I was working on before into E, wipe D (I don't think formatiing would be necessary) and copy the newly-active project onto D. When I then wanted to work on a different project I'd copy the current contents of D over the old version on E, wipe D and copy the newly-active project onto D. And so on. Got that?
BECAUSE: Access speed increases for sectors near the edge of the drive; copying onto an empty partition means files are automaticaly defragged; drive C:
must be the boot drive for most O/S (correct me if I'm wrong).
If I had two or more drives (and let's face it, they're not exactly expensive at the moment) - which I do - I would use one as a system drive and one as an audio drive, partitioned if necessary for projects and sample libraries, with the projects partition on the outside. I'd also consider a third, smaller drive for finished tracks
I really wouldn't worry too much about optimum performance though. In all my time with Cubase SX I have never seen the disk performance meter move above, oh, zero in play mode. It flickers when I locate or press start, but that's it. Modern hard drives are fast enough, believe me.
Hope this helps.