I have, Jack is more difficult to set up without the help of the distro packagers than you'd think.Hmm. Have you found your way to http://jackaudio.org/faq yet ? It's more useful than you'd think ...
I'd suggest playing before plunging...
That pure::dyne link before gives you a media-centered live distro. I doubt your netbook would be that chuffed with it but if you've a spare desktop it'd give you a basic idea of what the tools are in Linux-land...
Easy peasy, check checkinstall: http://openmaniak.com/checkinstall.php
Nay, not me. CHeers for the link! have you tried any VSTis in lmms yet?